Thermo Fisher Scientific FGFR1 Monoclonal Antibody (M2F12)
FGFR1 단백질을 특이적으로 인식하는 Thermo Fisher Scientific의 마우스 단클론 항체입니다. Western blot, IHC, ELISA, IP 등 다양한 응용에 사용 가능하며, 인간 및 랫트 시료에 반응합니다. 고순도 Protein A 정제, 액상 형태로 -20°C 보관.
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Applications
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (IHC): Assay-dependent
- ELISA: Assay-dependent
- Immunoprecipitation (IP): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M2F12 |
| Immunogen | Recombinant human FGF-R1-alpha (fibroblast growth factor receptor 1, alpha isoform) ectodomain |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533348 |
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family (FGFR1–4), which are membrane-spanning tyrosine kinases acting as high-affinity receptors for 17 growth factors (FGF1–17). This receptor family is essential for mesoderm induction, cell growth and migration, organ formation, and bone development.
FGFR1 undergoes alternative splicing, generating multiple variants expressed differently during embryonic and adult stages. Mutations or defects in FGFR1 are linked to disorders such as Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal aberrations involving FGFR1 are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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