Thermo Fisher Scientific LRP1 Monoclonal Antibody (A2MR-beta-1)
LRP1 단백질을 인식하는 Mouse monoclonal antibody (Clone A2MR-beta-1). Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 사용 가능. 인간, 마우스, 랫트 반응성. 단백질 A 정제, PBS buffer, -20°C 보관.
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- 377600
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | 7 publications |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:1,000 | - |
| Immunohistochemistry (Frozen) (IHC-F) | 1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:200 | - |
| Flow Cytometry (Flow) | Assay-dependent | - |
| ELISA | Assay-dependent | - |
| Immunoprecipitation (IP) | - | 3 publications |
| Miscellaneous PubMed (Misc) | - | 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A2MR-beta-1 |
| Immunogen | Synthetic peptide derived from the human CD91 beta chain |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533340 |
Product Specific Information
37-7600 was used in immunohistochemistry to successfully detect LRP-1 in mouse E18.5 lung sections.
Target Information
The LRP1 gene encodes an endocytic receptor involved in intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. It is essential for A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the major component of amyloid plaques in Alzheimer’s disease. Expression decreases with age and is reduced in Alzheimer patient brain tissue compared to controls.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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