Thermo Fisher Scientific TNNT1 Polyclonal Antibody

Thermo Fisher Scientific TNNT1 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Peptide Sequence: WIHQLESEKF DLMAKLKQQK YEINVLYNRI SHAQKFRKGA GKGRVGGRWK
• Sequence Homology:
  Cow: 100% / Dog: 100% / Guinea Pig: 100% / Horse: 100% / Human: 100% / Mouse: 100% / Rat: 100% / Zebrafish: 85%

Target Information

This gene encodes a protein that is a subunit of troponin, a regulatory complex located on the thin filament of the sarcomere. The complex regulates striated muscle contraction in response to intracellular calcium concentration. It consists of three subunits:

• Troponin C: binds calcium
• Troponin T: binds tropomyosin
• Troponin I: inhibitory subunit

TNNT1 encodes the slow skeletal troponin T subunit. Mutations in TNNT1 cause nemaline myopathy type 5 (Amish nemaline myopathy), a neuromuscular disorder characterized by muscle weakness and rod-shaped inclusions in skeletal muscle fibers, often leading to respiratory insufficiency in infancy. Multiple transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.