Thermo Fisher Scientific TNNT1 Polyclonal Antibody
TNNT1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot에 적합합니다. 인간 및 생쥐 반응성이 있으며, 합성 펩타이드 면역원으로 제작되었습니다. 액상 형태로 제공되며, -20°C에서 보관 시 안정적입니다.
- 카탈로그번호
- PA542109
- 판매단위
- pk
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Thermo Fisher Scientific TNNT1 Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 0.2–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human TNNT1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2609434 |
Product Specific Information
- Peptide Sequence: WIHQLESEKF DLMAKLKQQK YEINVLYNRI SHAQKFRKGA GKGRVGGRWK
- Sequence Homology:
Cow: 100% / Dog: 100% / Guinea Pig: 100% / Horse: 100% / Human: 100% / Mouse: 100% / Rat: 100% / Zebrafish: 85%
Target Information
This gene encodes a protein that is a subunit of troponin, a regulatory complex located on the thin filament of the sarcomere. The complex regulates striated muscle contraction in response to intracellular calcium concentration. It consists of three subunits:
- Troponin C: binds calcium
- Troponin T: binds tropomyosin
- Troponin I: inhibitory subunit
TNNT1 encodes the slow skeletal troponin T subunit. Mutations in TNNT1 cause nemaline myopathy type 5 (Amish nemaline myopathy), a neuromuscular disorder characterized by muscle weakness and rod-shaped inclusions in skeletal muscle fibers, often leading to respiratory insufficiency in infancy. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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