Thermo Fisher Scientific PLCG2 Polyclonal Antibody
Human PLCG2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P) 실험에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 0.1 mg/mL 농도의 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PLCG2. Recombinant protein control fragment (Product # RP-92496) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2789871 |
Product Specific Information
Immunogen sequence:
FGDLLLTKPT EASADQLPSP SQLREKIIIK HKKLGPRGDV DVNMEDKKDE HKQQGELYMW DSIDQKWTRH YCAIADAKLS FSDDIEQTME EEVPQDIPPT ELHFGEKWFH KK
Target Information
Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in receptor-mediated signal transduction by generating the second messengers inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate.
There are multiple mammalian PLC isozymes, including PLCβ1, PLCβ2, PLCβ3, PLCβ4, PLCγ1, PLCγ2, PLCδ1, PLCδ2, and PLCε.
PLCδ1 functions as a calcium signal amplifier and is activated by atypical GTP-binding proteins. It acts as an effector for transglutaminase II-mediated oxytocin receptor and α1B-adrenoreceptor signaling. Mouse PLCδ1 is highly expressed in brain, heart, lung, and testis. Abnormal accumulation of PLCδ is observed in Alzheimer’s disease brains, suggesting a role in AD pathology.
PLCδ2 is markedly expressed in type II intestinal metaplasia and adenocarcinoma. Its expression in type I intestinal metaplasia is generally benign but may evolve toward neoplastic transformation, making PLCδ2 a potential marker for gastric malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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