Thermo Fisher Scientific AKR1B10 Polyclonal Antibody
Human AKR1B10 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC 등 다양한 응용에 적합함. 항원 친화 크로마토그래피로 정제된 고순도 항체로, 안정적인 액상 형태이며 장기 보관 시 -20°C에서 유지 가능. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human AKR1B10. Recombinant protein control fragment (Product #RP-92849). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789874 |
Product Specific Information
Immunogen sequence:
PTFFERPLVR KAFEKTLKDL KLSYLDVYLI HWPQGFKSGD DLFPKDDKGN AIGGKAT
Target Information
AKR1B10 is a 316 amino acid protein that catalyzes efficient reduction of aliphatic and aromatic aldehydes. It is the first cytosolic NADP(H)-dependent retinal reductase described in humans, characterized by the presence of a novel NADP binding motif.
Due to its ability to convert glucose to sorbitol, AKR1B10 may play a role in the development of secondary diabetic complications. It is abundantly expressed in adrenal gland, small intestine, and colon, with lower levels in liver, thymus, prostate, testis, and skeletal muscle. Its levels are upregulated in certain cancers such as hepatocellular carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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