Thermo Fisher Scientific CD46 Monoclonal Antibody (1B6)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

10 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgM, kappa

Class

Monoclonal

Type

Antibody

Clone

1B6

Immunogen

CD46 (AAH30594, 36 a.a. approximately 135 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CD46,uniProtId:P15529-1,ncbiNodeId:9606,antigenRange:36-135,antigenLength:392,antigenImageFileName:H00004179-M14A_CD46_P15529-1_House_mouse.svg,antigenImageFileNamePDP:H00004179-M14A_CD46_P15529-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Storage buffer

ascites

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: EEPPTFEAME LIGKPKPYYE IGERVDYKCK KGYFYIPPLA THTICDRNHT WLPVSDDACY RETCPYIRDP LNGQAVPANG TYEFGYQMHF ICNEGYYLIG

Target Information

CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.