Thermo Fisher Scientific UPF2 Polyclonal Antibody
Human UPF2 단백질을 인식하는 Rabbit Polyclonal Antibody로, ICC/IF 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공됩니다. 4°C 단기 보관 또는 -20°C 장기 보관을 권장합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human UPF2 (Product #RP-107535) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664819 |
Product Specific Information
Immunogen sequence:
LTRKGNKQQFK ILNVPMSSQL AANHWNQQQA EQEERMRMKK LTLDINERQE QEDYQEMLQS LAQRPAPANT NRERRPRYQH PKGAPNADLI FKTGG
Highest antigen sequence identity to the following orthologs:
- Mouse: 100%
- Rat: 92%
Target Information
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance.
mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD).
When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons.
This protein is located in the perinuclear area and interacts with translation release factors and proteins homologous to yeast Upf1p and Upf3p.
Two splice variants have been found for this gene; both encode the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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