Thermo Fisher Scientific COL1A1 Monoclonal Antibody (3G3)
COL1A1 단백질을 인식하는 Mouse IgG3 단클론 항체로, Western Blot 및 ELISA에 적합합니다. COL1A1 관련 질환 연구 및 단백질 발현 분석에 활용 가능하며, PBS 기반 액상 형태로 제공됩니다. -20°C 보관 권장.
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Thermo Fisher Scientific COL1A1 Monoclonal Antibody (3G3)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-Dependent |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG3, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3G3 |
| Immunogen | COL1A1 (NP_000079.1, 1021–1108 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
EGSPGRDGSP GAKGDRGETG PAGPPGAPGA PGAPGPVGPA GKSGDRGETG PAGPAGPVGP VGARGPAGPQ GPRGDKGETG EQGDRGIK
Target Information
The protein encoded by this gene is the pro-alpha1 chain of type I collagen, forming a triple helix with two alpha1 chains and one alpha2 chain. Type I collagen is a fibril-forming collagen found in connective tissues such as bone, cornea, dermis, and tendon.
Mutations in COL1A1 are associated with:
- Osteogenesis imperfecta types I–IV
- Ehlers-Danlos syndrome type VIIA and Classical type
- Caffey Disease
- Idiopathic osteoporosis
Reciprocal translocations between chromosomes 17 and 22 involving COL1A1 and PDGFB are linked to dermatofibrosarcoma protuberans, causing unregulated growth factor expression. Two transcripts have been identified from alternate polyadenylation signals.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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