Thermo Fisher Scientific ZC3H12B Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ZC3H12B. Recombinant protein control fragment (Product #RP-91996). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ZC3H12B,uniProtId:Q5HYM0-1,ncbiNodeId:9606,antigenRange:693-801,antigenLength:836,antigenImageFileName:PA5-51464_ZC3H12B_Q5HYM0-1_Rabbit.svg,antigenImageFileNamePDP:PA5-51464_ZC3H12B_Q5HYM0-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2649796

Product Specific Information

Immunogen sequence: GRALVMTRMD SISDSRLYES NPVRQRRPPL CREQHASWDP LPCTTDSYGY HSYPLSNSLM QPCYEPVMVR SVPEKMEQLW RNPWVGMCND SREHMIPEHQ YQTYKNLCN

Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.

Target Information

ZC3H12B, also known as MCPIP2, is a member of a family of novel CCCH-zinc finger proteins that regulate macrophage activation and may be involved in host immunity and inflammatory diseases. The function of ZC3H12B is not well understood. Unlike other members of the ZC3H12 family, ZC3H12B has a RasGEF domain at the C-terminal of the zinc finger motif, suggesting its potential involvement in Ras-mediated signal transduction. It is highly expressed in brain, thymus, and testis, but unlike ZC3H12A and ZC3H12C, not expressed in macrophages after treatment with lipopolysaccharide (LPS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.