Thermo Fisher Scientific MAPK8IP1 Monoclonal Antibody (OTI3A12), TrueMAB
인간 MAPK8IP1 단백질을 인식하는 Mouse IgG2b 단일클론 항체로 Western blot에 최적화. Affinity chromatography로 정제된 액상 형태이며, PBS/BSA/glycerol buffer에 보존. 베타세포 기능 및 MAPK8 경로 연구용에 적합.
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Thermo Fisher Scientific MAPK8IP1 Monoclonal Antibody (OTI3A12), TrueMAB
Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3A12 |
| Immunogen | Full length human recombinant protein of human MAPK8IP1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene is a regulator of pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to regulate c-Jun amino-terminal kinase (MAPK8). This protein prevents MAPK8-mediated activation of transcription factors and reduces IL-1 beta and MAP kinase kinase 1 (MEKK1)-induced apoptosis in pancreatic beta cells. It also acts as a DNA-binding transactivator of the glucose transporter GLUT2. REST (RE1-silencing transcription factor) represses expression of this gene in insulin-secreting beta cells. Mutations in this gene have been associated with type 2 diabetes susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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