Thermo Fisher Scientific Phospho-PKC gamma (Thr514) Polyclonal Antibody
PKC gamma 단백질의 Thr514 인산화 형태를 인식하는 Rabbit Polyclonal Antibody로, 인간 및 생쥐 시료에 반응합니다. Western blot 및 IHC(Paraffin) 분석에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:100 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Hamster |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Chemically synthesized phosphopeptide derived from human PKC-gamma containing threonine 514 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533806 |
Target Information
The PKC family of serine/threonine kinases, including PRKCG (PKC gamma), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action, response to extracellular signals, and substrate specificity.
PKC alpha, beta I, beta II, and gamma form the conventional family whose activities are Ca²⁺- and phospholipid-dependent. Protein kinase C can be activated by calcium and diacylglycerol. PKC family members phosphorylate diverse protein targets and play roles in various cellular signaling pathways. PKC also serves as a major receptor for phorbol esters, a class of tumor promoters.
PKC gamma is expressed exclusively in the brain and spinal cord and localized to neurons. It is involved in neuronal functions such as long-term potentiation (LTP) and long-term depression (LTD). Knockout studies in mice suggest a role in neuropathic pain development. Defects in PKC gamma are associated with spinocerebellar ataxia-14 (SCA14).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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