Thermo Fisher Scientific CD8A (Cytotoxic- and Suppressor T-Cell Marker) Polyclonal Antibody
CD8A 단백질을 인식하는 Rabbit Polyclonal Antibody로, 인간 시료에 반응합니다. IHC(P), IHC(PFA), Flow Cytometry에 사용 가능하며, 1 mg/mL 농도의 액상 형태입니다. 단백질 A/G로 정제되었으며, PBS(pH 7.4) 버퍼에 보존제로 없이 제공됩니다.
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Thermo Fisher Scientific CD8A (Cytotoxic- and Suppressor T-Cell Marker) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Item | Specification |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment from human CD8 C-terminal cytoplasmic domain of alpha chain |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family that plays a critical role in signal transduction, T cell differentiation, and activation. It is mainly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor for MHC class I molecules. CD8α is essential for MHC-I binding and is also found on NK cells, monocytes, and dendritic cells as homodimers. Engagement of MHC-I/peptide complexes recruits Lck kinase, leading to lymphokine production and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are key in pathogen and tumor cell clearance, and their differentiation is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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