Thermo Fisher Scientific TSC1 Polyclonal Antibody
TSC1 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체입니다. Western blot, IHC, ICC/IF 등 다양한 응용에 사용 가능하며, 인간에 반응하고 마우스에서도 보고되었습니다. 0.5 mg/mL 농도의 액상 시약으로 -20°C 보관 권장.
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Thermo Fisher Scientific TSC1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–0.3 µg/mL | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–4 µg/mL | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (QLHIMDYNETHHEH) corresponding to the C-terminus amino acids of TSC1 (aa 1150–1164) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10985558 |
Product Specific Information
- Predicted to react with canine, mouse, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes.
The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), a serine/threonine kinase regulating cell growth and cycle through nutrient and growth factor integration.
TOR activity is stimulated by Rheb, a Ras superfamily G-protein member, when the GTP/GDP ratio bound to Rheb is high.
Immunoprecipitated TSC1/TSC2 stimulates Rheb GTPase activity in vitro, decreasing Rheb-mediated TOR activation.
Overexpression of TSC1 and TSC2 reduces Rheb GTP/GDP ratio and inhibits cell growth.
A shorter 40 kDa isoform of TSC1 exists, but its function remains unknown.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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