Thermo Fisher Scientific Resistin Polyclonal Antibody
Resistin 단백질을 인식하는 Rabbit Polyclonal Antibody로 IHC(P) 및 ELISA에 적합. Mouse와 Rat 시료 반응성. KLH 결합 합성 펩타이드 유래 항원 사용. 고순도 Protein A 정제, -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:400 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from rat Resistin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Adipose tissue acts as an energy reserve and produces various physiologically important proteins such as lipoprotein lipase (LPL), leptin, Acrp30, perilipin, and resistin.
Resistin, also known as Adipocyte Secreted Factor (ADSF) and FIZZ3, is a cytokine secreted specifically by adipocytes. It has been implicated in paracrine signaling and type 2 diabetes.
Studies show increased serum resistin levels in obese, diabetic mice, correlating with insulin antagonism. Resistin has been linked to insulin resistance and glucose intolerance in mice.
Its gene expression requires C/EBP alpha and is activated by coactivators CBP and p300 through histone acetylation at the resistin promoter. PPAR gamma and RXR ligands have been shown to downregulate resistin expression in adipocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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