Thermo Fisher Scientific UNC13D Monoclonal Antibody (1E11)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

ELISA (ELISA)

1 ng/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

1E11

Immunogen

UNC13D (NP_954712.1, 2 a.a. approximately 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Munc13-4,uniProtId:Q70J99-1,ncbiNodeId:9606,antigenRange:2-100,antigenLength:1090,antigenImageFileName:H00201294-M06_Munc13-4_Q70J99-1_House_mouse.svg,antigenImageFileNamePDP:H00201294-M06_Munc13-4_Q70J99-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: ATLLSHPQQR PPFLRQAIKI RRRRVRDLQD PPPQMAPEIQ PPSHHFSPEQ RALLYEDALY TVLHRLGHPE PNHVTEASEL LRYLQEAFHV EPEEHQQTL

Target Information

This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.