Thermo Fisher Scientific WNK2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human WNK2. Recombinant protein control fragment (Product #RP-91472). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:WNK2,uniProtId:Q9Y3S1-1,ncbiNodeId:9606,antigenRange:1676-1803,antigenLength:2297,antigenImageFileName:PA5-53440_WNK2_Q9Y3S1-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53440_WNK2_Q9Y3S1-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2649658

Product Specific Information

Immunogen sequence: GTSSSMTAES SPRSMLGYDR DGRQVASDSH VVPSVPQDVP AFVRPARVEP TDRDGGEAGE SSAEPPPSDM GTVGGQASHP QTLGARALGS PRKRPEQQDV SSPAKTVGRF SVVSTQDEWT LASPHSLR

Highest antigen sequence identity to the following orthologs: Mouse - 60%, Rat - 59%.

Target Information

WNK2 is a serine/threonine kinase involved in signal transduction and cellular communication. WNK kinases contain a lysine upstream of the traditional position, within a glycine string. This lysine functions as an anchor and orients ATP through interactions with the alpha and beta phosphoryl groups. The catalytic domains of WNK2, WNK3 and WNK4 are 95% homologous to WNK1. The human WNK1 gene encodes a 2,382 amino acid protein that is primarily expressed in heart, kidney, muscle and distal nephron. The human WNK3 gene encodes a protein that is primarily expressed in brain; the human WNK4 gene encodes a 1,243 amino acid protein that is expressed in kidney. Aberrant function of WNK kinases and their associated signaling pathways are implicated in hypertension, increased renal salt reabsorption and impaired K+ and H+ excretion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.