Thermo Fisher Scientific WNK2 Polyclonal Antibody
Thermo Fisher Scientific의 WNK2 Polyclonal Antibody는 인간 WNK2 단백질을 타겟으로 하는 Rabbit IgG 폴리클로날 항체입니다. Western blot 및 IHC(P) 실험에 적합하며, 높은 특이성과 재현성을 제공합니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA553440
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human WNK2. Recombinant protein control fragment (Product #RP-91472). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649658 |
Product Specific Information
Immunogen sequence:
GTSSSMTAES SPRSMLGYDR DGRQVASDSH VVPSVPQDVP AFVRPARVEP TDRDGGEAGE SSAEPPPSDM GTVGGQASHP QTLGARALGS PRKRPEQQDV SSPAKTVGRF SVVSTQDEWT LASPHSLR
- Highest antigen sequence identity to the following orthologs:
- Mouse: 60%
- Rat: 59%
Target Information
WNK2 is a serine/threonine kinase involved in signal transduction and cellular communication. WNK kinases contain a lysine upstream of the traditional position within a glycine string. This lysine functions as an anchor and orients ATP through interactions with the alpha and beta phosphoryl groups. The catalytic domains of WNK2, WNK3, and WNK4 are 95% homologous to WNK1.
The human WNK1 gene encodes a 2,382 amino acid protein primarily expressed in heart, kidney, muscle, and distal nephron.
The human WNK3 gene encodes a protein primarily expressed in brain, and WNK4 is expressed in kidney.
Aberrant function of WNK kinases and their associated signaling pathways are implicated in hypertension, increased renal salt reabsorption, and impaired K⁺ and H⁺ excretion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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