Thermo Fisher Scientific DERL1 Polyclonal Antibody
Human DERL1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 제품이며, 0.1 mg/mL 농도. ERAD 관련 단백질 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DERL1. Recombinant protein control fragment (Product # RP-91209) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640532 |
Product Specific Information
Immunogen sequence:
LMFRYPMDLG GRNFLSTPQF LYRWLPSRRG GVSGFGVPPA SMRRAADQNG GGGRHNWGQG FRLGDQ
Sequence identity:
- Mouse: 100%
- Rat: 100%
Target Information
DERL1 is a functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. It may form a channel that enables retrotranslocation of misfolded proteins into the cytosol for ubiquitination and proteasomal degradation. DERL1 mediates interactions between VCP and degradation substrates and plays a key role in cytomegalovirus infection by facilitating degradation of MHC class I heavy chains via US11 viral protein interaction. Also involved in the degradation of misfolded cytomegalovirus US2 protein.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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