Thermo Fisher Scientific TEM5 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 158-271. Recombinant protein control fragment (Product #RP-109719). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TEM5,uniProtId:Q96PE1-1,ncbiNodeId:9606,antigenRange:158-271,antigenLength:1338,antigenImageFileName:PA5-144689_TEM5_Q96PE1-1_Rabbit.svg,antigenImageFileNamePDP:PA5-144689_TEM5_Q96PE1-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3092214

Product Specific Information

Immunogen sequence: LLRLNISGNI FSSLQPGVFD ELPALKVVDL GTEFLTCDCH LRWLLPWAQN RSLQLSEHTL CAYPSALHAQ ALGSLQEAQL CCEGALELHT HHLIPSLRQV VFQGDRLPFQ CSAS

Antigen sequence identity: Mouse 89%; Rat 89%

Target Information

Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogensis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies. These include TEMs such as TEM1, TEM5, TEM7 and TEM8. TEM5 is a member of the adhesion family of G protein coupled receptors and is localized on the surface of endothelial cells. TEM5 is a seven-pass transmembrane receptor, unlike TEM1, TEM7 and TEM8 which span the membrane once. TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.