Thermo Fisher Scientific TEM5 Polyclonal Antibody
TEM5 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody. 인간 시료에 반응하며, ICC/IF에 0.25–2 µg/mL로 사용 가능. 액상 형태, Affinity chromatography로 정제됨. 항-혈관신생 연구용으로 적합.
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Applications
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence (range: 158–271). Recombinant protein control fragment (Product #RP-109719). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3092214 |
Product Specific Information
- Immunogen sequence:
LLRLNISGNI FSSLQPGVFD ELPALKVVDL GTEFLTCDCH LRWLLPWAQN RSLQLSEHTL CAYPSALHAQ ALGSLQEAQL CCEGALELHT HHLIPSLRQV VFQGDRLPFQ CSAS - Antigen sequence identity: Mouse 89%; Rat 89%
Target Information
Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for the development of anti-angiogenic therapies. These include TEM1, TEM5, TEM7, and TEM8.
TEM5 is a member of the adhesion family of G protein-coupled receptors and is localized on the surface of endothelial cells. It is a seven-pass transmembrane receptor, unlike TEM1, TEM7, and TEM8 which span the membrane once. TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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