Thermo Fisher Scientific IL-1 beta Recombinant Rabbit Monoclonal Antibody (17H18L16)
IL-1 beta 단백질을 표적으로 하는 Thermo Fisher recombinant rabbit monoclonal 항체. Western blot, Flow cytometry, Immunoprecipitation에 사용 가능. 높은 특이성과 일관된 로트 간 품질 제공. 연구용으로 인체 진단용 아님.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2–3 µg/mL | View 4 publications |
| Flow Cytometry (Flow) | – | View 1 publication |
| Immunoprecipitation (IP) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Bacteria, Chicken, Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 17H18L16 |
| Immunogen | Recombinant protein corresponding to amino acids 118–269 of mouse IL-1 beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2532466 |
Product Specific Information
This antibody is predicted to react with non-human primate, rabbit, and rat based on sequence homology.
Intact IgG appears on a non-reducing gel as a ~150 kDa band, and upon reduction generates a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized as a 31 kDa inactive pro-form that accumulates in the cytosol. Activation of inflammasomes triggers cleavage by caspase-1 into the active 17 kDa form.
IL-1 beta lacks a signal sequence for classical secretion and is released via an alternate mechanism. It signals through IL-1RI and IL-1RII receptors, shared with IL-1 alpha. Its activity is moderated by IL-1 Receptor Antagonist (IL-1RA).
IL-1 beta plays a key role in innate host defense by inducing other proinflammatory cytokines and acute-phase responses. Elevated levels are associated with chronic inflammatory conditions, and IL-1 beta neutralizing antibodies have potential therapeutic value.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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