Thermo Fisher Scientific IL-1 beta Recombinant Rabbit Monoclonal Antibody (17H18L16)
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
701304 | - | Thermo Fisher Scientific 701304 IL-1 beta Recombinant Rabbit Monoclonal Antibody (17H18L16) 100 ug pk | 재고문의 | pk | 628,000원 | - | 690,800원 |
다른 상품 둘러보기
Applications
Tested Dilution
Publications
Western Blot (WB)
2-3 µg/mL
View 4 publications 4 publications
Flow Cytometry (Flow)
-
View 1 publication 1 publication
Immunoprecipitation (IP)
-
View 1 publication 1 publication
Product Specifications
Species Reactivity
Human, Mouse
Published species
Bacteria, Chicken, Human, Mouse
Host/Isotype
Rabbit / IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
17H18L16
Immunogen
Recombinant protein corresponding to amino acids 118-269 of mouse IL-1 if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
IL-1 beta,
uniProtId:
P10749-1,
ncbiNodeId:
10090,
antigenRange:
118-269,
antigenLength:
269,
antigenImageFileName:
701304_IL-1_beta_P10749-1_Rabbit.svg,
antigenImageFileNamePDP:
701304_IL-1_beta_P10749-1_Rabbit_PDP.jpeg,
sortOrder:
2}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2532466
Product Specific Information
This antibody is predicted to react with non-human primate, rabbit and rat based on sequence homology.
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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