Thermo Fisher Scientific TMP21 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human TMP21 (TMED10). Validated for WB and IHC-P. Supplied as liquid, 0.1 mg/mL in PBS with 40% glycerol. For research use only.
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- PA584012
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TMED10. Recombinant protein control fragment (Product #RP-99885). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2791164 |
Product Specific Information
Immunogen sequence:
SFHLPINSRK CLREEIHKDL LVTGAYEISD QSGGAGGLRS HLKITDSAGH ILYSKEDATK GKFAFTTEDY D
Target Information
TMP21 (TMED10) is a ubiquitously expressed protein involved in vesicular targeting and protein transport. It is a component of the presenilin complex and modulates the γ-secretase, but not the ε-secretase, cleavage activity of the amyloid precursor protein (APP). The presenilin complex includes APH1, nicastrin, PEN2, and presenilin-1, which together cleave APP at γ- and ε-sites, leading to accumulation of the Aβ cleavage product associated with Alzheimer’s disease.
Co-immunoprecipitation experiments indicate that TMP21 may regulate this complex. Suppression of TMP21 expression by siRNA increases γ-secretase activity and Aβ production, showing TMP21’s role in modulating γ-secretase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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