Thermo Fisher Scientific EPOR Monoclonal Antibody (OTI4F12), TrueMAB
인간 EPOR 단백질을 인식하는 단일클론 항체로 Western blot 및 IHC(Paraffin) 실험에 적합합니다. 고순도 액상 형태로 제공되며, 안정적인 PBS/BSA/glycerol 버퍼에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4F12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 25–250 of human EPOR produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
EpoR encodes the erythropoietin receptor, a member of the cytokine receptor family. When erythropoietin binds to this receptor, it activates Jak2 tyrosine kinase and downstream signaling pathways, including Ras/MAP kinase, PI3K, and STAT transcription factors. This activation supports erythroid cell survival.
Defects in this gene may lead to erythroleukemia and familial erythrocytosis, and dysregulation can influence tumor growth. Multiple transcript variants exist due to alternative splicing.
Diseases associated with EPOR include Erythrocytosis, Familial, 1 and Erythroleukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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