Thermo Fisher Scientific G0S2 Polyclonal Antibody
G0S2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 아포토시스 및 지방대사 연구에 활용됩니다. 고순도 Affinity 정제 및 안정한 PBS/glycerol buffer로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 1–100 of human G0S2 (NP_056529.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.15 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS (pH 7.3) with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855159 |
Product Specific Information
Immunogen sequence:
METVQELIPL AKEMMAQKRK GKMVKLYVLG SVLALFGVVL GLMETVCSPF TAARRLRDQE AAVAELQAAL ERQALQKQAL QEKGKQQDTV LGGRALSNRQ
Target Information
The G(0)-G(1) switch gene 2 (G0S2) encodes a mitochondrial protein involved in apoptosis, lipolysis, and triacylglycerol hydrolysis.
In adipocytes, G0S2 binds to adipose triglyceride lipase, reducing lipid droplet breakdown. Elevated G0S2 expression correlates with lipid accumulation in Crohn’s colitis.
Mutations in G0S2 are frequent in squamous lung cancer, while epigenetic silencing occurs in breast cancer, impairing apoptotic regulation. When not silenced, G0S2 mediates Bcl-2/Bax heterodimer formation, promoting apoptosis in cancerous cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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