Thermo Fisher Scientific ADAP Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Immunogen sequence:
NEGSSFPAPP KQLDMGDEVY DDVDTSDFPV SSAEMSQGTN VGKAKTEEKD LKKLKKQEKE EKDFRKKFKY DGEIRVLYST KVTTSITSKK WGTRDLQVKP GESLEVIQTT DDTKVLCRNE EGKYGYVLRS YLADNDGEIY DDIADGCIYD ND

Target Information

The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappa-B family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell–antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.