Thermo Fisher Scientific GbetaL Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Predicted to react with Rat, Zebrafish, X. laevis, X. tropicalis, and Bovine based on 100% sequence identity

Target Information

G-protein beta subunit-like (GBL protein) is a novel member of the WD-40 protein family. It is a highly conserved cytosolic protein consisting of seven WD-40 repeating motifs. LST8 is a functional component of the mTOR signaling complex (TORC1) and positively regulates the mTOR pathway. It interacts with the kinase domain of mTOR and stabilizes its interaction with raptor. LST8 participates in regulating cell growth and nutrient- and growth factor-mediated mTOR signaling to S6K1. Reports suggest up-regulated expression of LST8 due to insulin, indicating a possible role in intracellular events related to insulin-receptor activation, including insulin-stimulated glucose transport and glycogen synthesis. Northern blot analysis detected ubiquitous expression of LST8 with highest expression in brain and testis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

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