Thermo Fisher Scientific IP3 Receptor 2 Polyclonal Antibody

Thermo Fisher Scientific IP3 Receptor 2 Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1 µg/mL
Publications: -

Product Specifications

Product Specific Information

Peptide sequence:
FRDCLFKVCP MNRYSAQKQY WKAKQAKQGN HTEAALLKKL QHAAELEQKQ

Sequence homology:
Cow: 100% | Dog: 100% | Guinea Pig: 100% | Horse: 100% | Human: 100% | Mouse: 100% | Rabbit: 100% | Rat: 100% | Zebrafish: 100%

Target Information

Inositol 1,4,5-trisphosphate (IP3) is a second messenger for many growth factors, hormones, and neurotransmitters. Upon binding to IP3R, IP3 triggers the release of intracellular luminal calcium into the cytosol. Functional IP3R forms homo- or heterotetramers of ~240 kDa glycoprotein subunits.
IP3R protein is structurally and functionally related to the ryanodine receptor, and both can associate with the immunophilin protein FKBP12. Phosphorylation of IP3R by PKC enhances IP3-mediated calcium release, while dephosphorylation by calcineurin reduces it, leading to calcium oscillations.
Mammalian IP3R subunits are encoded by three distinct genes with differential expression:

• IP3R-I: heart, liver, kidney, ovary, Purkinje neurons
• IP3R-II: predominantly brain
• IP3R-III: pancreatic islets, kidney, gastrointestinal tract

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

제품 이미지

(이미지 파일명: PA5-41009_IP3_Receptor_2_Q14571-1_Rabbit.svg, PA5-41009_IP3_Receptor_2_Q14571-1_Rabbit_PDP.jpeg)