Thermo Fisher Scientific IP3 Receptor 2 Polyclonal Antibody
IP3 Receptor 2에 특이적인 Rabbit Polyclonal Antibody로, Western blot에 최적화되어 있습니다. 인간을 포함한 다양한 종에 반응하며, 액상 형태로 0.5 mg/mL 농도입니다. Affinity Chromatography로 정제되어 안정적인 신호 검출을 제공합니다.
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Thermo Fisher Scientific IP3 Receptor 2 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1 µg/mL
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human ITPR2 (aa 53–102) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2607847 |
Product Specific Information
Peptide sequence:
FRDCLFKVCP MNRYSAQKQY WKAKQAKQGN HTEAALLKKL QHAAELEQKQ
Sequence homology:
Cow: 100% | Dog: 100% | Guinea Pig: 100% | Horse: 100% | Human: 100% | Mouse: 100% | Rabbit: 100% | Rat: 100% | Zebrafish: 100%
Target Information
Inositol 1,4,5-trisphosphate (IP3) is a second messenger for many growth factors, hormones, and neurotransmitters. Upon binding to IP3R, IP3 triggers the release of intracellular luminal calcium into the cytosol. Functional IP3R forms homo- or heterotetramers of ~240 kDa glycoprotein subunits.
IP3R protein is structurally and functionally related to the ryanodine receptor, and both can associate with the immunophilin protein FKBP12. Phosphorylation of IP3R by PKC enhances IP3-mediated calcium release, while dephosphorylation by calcineurin reduces it, leading to calcium oscillations.
Mammalian IP3R subunits are encoded by three distinct genes with differential expression:
- IP3R-I: heart, liver, kidney, ovary, Purkinje neurons
- IP3R-II: predominantly brain
- IP3R-III: pancreatic islets, kidney, gastrointestinal tract
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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(이미지 파일명: PA5-41009_IP3_Receptor_2_Q14571-1_Rabbit.svg, PA5-41009_IP3_Receptor_2_Q14571-1_Rabbit_PDP.jpeg)
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