Thermo Fisher Scientific Human CD25 (IL-2R alpha) (soluble) Recombinant Protein, PeproTech
인간 CD25(IL-2Rα) 재조합 단백질로, CHO 세포에서 발현되며 ≥98% 순도를 보유. IL-2의 증식 효과를 증가시키는 생물학적 활성을 가짐. 면역세포 연구 및 기능 분석에 적합. 동결건조 형태로 제공되며, -20°C에서 보관.
- 카탈로그번호
- 200-02RC-xxxxx (5개 옵션)
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
5개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human CD25 (IL-2R alpha) (soluble) Recombinant Protein, PeproTech
Applications
Western Blot (WB)
- Assay-dependent
ELISA
- Assay-dependent
Functional Assay
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | CHO cells |
| Amino Acid Sequence | ELCDDDPPEI PHATFKAMAY KEGTMLNCEC KRGFRRIKSG SLYMLCTGNS SHSSWDNQCQ CTSSATRNTT KQVTPQPEEQ KERKTTEMQS PMQPVDQASL PGHCREPPPW ENEATERIYH FVVGQMVYYQ CVQGYRALHR GPAESVCKMT HGKTRWTQPQ LICTGEMETS QFPGEEKPQA SPEGRPESET SCLVTTTDFQ IQTEMAATME TSIFTTEYQ |
| Molecular Weight | 24.8 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | <1 EU/µg |
| Activity | Increases proliferation effect of IL-2 in murine CTLL-2 cells. In presence of 1 ng/ml recombinant IL-2, ED50 is 0.5–1.5 µg/ml |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
- Catalog No. 200-02RC-1MG is supplied as 2 × 500 µg (200-02RC-500UG).
- Recombinant Human sIL-2 Receptor alpha is a 24.8 kDa protein containing 219 amino acids, representing only the extracellular domain of IL-2Rα.
- Due to glycosylation, it migrates at approximately 40–50 kDa by SDS-PAGE under reducing and non-reducing conditions.
- Shipped at ambient temperature.
- Refer to the lot-specific Certificate of Analysis for storage, handling, and reconstitution details.
Target Information
CD25 (IL-2 receptor alpha chain, IL2RA) is a cytokine receptor involved in the proliferation of T and B lymphocytes.
The IL2RA forms part of a heterotrimeric receptor complex with IL2RB and IL2RG, creating a high-affinity IL-2 receptor.
Homodimeric IL2RA chains form low-affinity receptors, while IL2RB homodimers form medium-affinity receptors.
IL2 expression in mature thymocytes is monoallelic, representing a unique regulatory mechanism for gene expression.
IL2, primarily produced by mature T cells, functions as a growth and differentiation factor and regulates cell death.
It stimulates B cell proliferation, enhances NK cell activity, and inhibits granulocyte macrophage colony formation.
Disruption of the corresponding gene in mice leads to ulcerative colitis-like disease, suggesting a role in immune response.
Mutations in this gene are associated with interleukin-2 receptor alpha deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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