Thermo Fisher Scientific WWOX Polyclonal Antibody
WWOX 단백질을 인식하는 Rabbit Polyclonal 항체로, ELISA 및 Dot blot에 사용 가능. 합성 펩타이드 면역원 기반으로 제작되었으며 비결합형 액상 형태. Rat, Mouse, Human 시료에서 검출 가능하며, 암 억제 및 세포사멸 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| ELISA (ELISA) | 1:10,000–1:100,000 |
| Dot blot (DB) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide KVSLFWGWARHRSLC conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_1961379 |
Product Specific Information
PA1-31219 detects WWOX3 from rat, mouse, and human samples.
Target Information
WW domain-containing proteins are found in all eukaryotes and play important roles in regulating various cellular functions such as protein degradation, transcription, and RNA splicing.
This gene encodes a protein containing two WW domains and a short-chain dehydrogenase/reductase domain (SRD).
Highest expression is observed in hormonally regulated tissues including testis, ovary, and prostate, suggesting a role in steroid metabolism.
The encoded protein shares over 90% identity with the mouse ortholog, an essential mediator of TNF-alpha-induced apoptosis, implying a similar apoptotic role in humans.
Additionally, this gene may function as a tumor growth suppressor. Alternative splicing generates multiple transcript variants encoding different isoforms.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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