Thermo Fisher Scientific PDE11A Polyclonal Antibody, FITC
FITC 형광 표지된 PDE11A 폴리클로날 항체로, Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. 사람, 생쥐, 랫트 시료에서 반응하며, 고순도의 친화 크로마토그래피 정제 제품입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 100–150 on PDE11A protein, common to all PDE11A variants |
| Conjugate | FITC (Fluorescein) |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, store in the dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
3’,5’-cyclic nucleotides (cAMP and cGMP) act as second messengers in numerous signal transduction pathways. 3’,5’-cyclic nucleotide phosphodiesterases (PDEs) hydrolyze cAMP and cGMP to their corresponding 5’-monophosphates, providing a mechanism to downregulate cAMP and cGMP signaling. The PDE11A gene encodes a member of the PDE protein superfamily. Mutations in this gene are associated with Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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