Thermo Fisher Scientific BRD7 Polyclonal Antibody
BRD7 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합하며, 인간 시료에 반응. 고순도 항원 친화 크로마토그래피로 정제된 액상 항체. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
- Publications: 없음
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
- Publications: 없음
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human BRD7 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2735535 |
Product Specific Information
- Positive Control: HeLa, HeLa nuclear extract
- Predicted Reactivity: Mouse (85%), Rat (84%), Bovine (88%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
BRD7 acts both as coactivator and as corepressor. It activates the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating GSK3B activity. It is required for TP53-mediated cell-cycle arrest in response to oncogene activation. BRD7 promotes acetylation of TP53 at Lys-382, facilitating TP53 recruitment to target promoters and inhibiting cell cycle progression from G1 to S phase.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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