Thermo Fisher Scientific p70 S6 Kinase Polyclonal Antibody
Human 및 Mouse 반응성을 가진 Rabbit polyclonal antibody로 p70 S6 Kinase를 인식합니다. Western blot, ELISA, IP에 적합하며, 액상 형태로 제공됩니다. Affinity chromatography로 정제되어 안정적이며 연구용으로만 사용됩니다.
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Thermo Fisher Scientific p70 S6 Kinase Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| ELISA | 1:5,000 |
| Immunoprecipitation (IP) | 5 µg/mg |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Affinity purified antibody prepared from rabbit serum immunized with a synthetic peptide corresponding to the carboxy terminal end of human p70S6K protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.1M Tris HCl/TBS, pH 8 |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid (dilute only prior to immediate use).
Target Information
RPS6KB1 (p70S6K) is a serine/threonine kinase with two non-identical kinase catalytic domains that phosphorylates several residues of the S6 ribosomal protein. This kinase is predominantly localized in the cytoplasm and plays an essential role in cell proliferation regulated by growth factors, as well as pathways involving cell motility, immune response, and tissue repair.
p70 S6 kinase acts downstream of phosphoinositide (PI) 3-kinase, targeting the S6 ribosomal protein to upregulate protein synthesis. Increased activity of p70 S6 kinase leads to enhanced protein synthesis and cell proliferation. Amplification and overexpression of p70 S6 kinase are observed in certain breast cancer cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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