Thermo Fisher Scientific ATXN7L3 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human ATXN7L3. Validated for Western blot and immunoprecipitation. Supplied as liquid, 1 mg/mL concentration. Recommended storage at 4°C, shipped on wet ice. Predicted to cross-react with mouse ATXN7L3.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 | — |
| Immunoprecipitation (IP) | Assay-dependent | — |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 297 and 347 of human Ataxin 7-Like 3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination.
Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879).
The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription.
Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972).
Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22, and ATXN7L3B (PubMed:27601583).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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