Thermo Fisher Scientific CCR5 Polyclonal Antibody
CCR5 단백질을 검출하기 위한 Rabbit Polyclonal Antibody로, 인간 및 설치류 등 다양한 종에 반응합니다. Western blot 및 Immunocytochemistry에 적합하며, 고순도 친화 크로마토그래피로 정제되었습니다. HIV 연구 및 세포 수용체 분석에 활용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CCR5 (Accession P51681), corresponding to amino acid residues V310–L352 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899601 |
Product Specific Information
Antibody detects endogenous levels of total CCR5.
Target Information
Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains, facilitating fusion and entry into human white blood cells. CCR5 is essential for infection by HIV-1, HIV-2, and SIV. Beta-chemokines RANTES, MIP-alpha, and MIP-beta act as ligands for CCR5 and can prevent infection by M-tropic HIV-1. CCR5 associates with the CD4-gp120 complex on the HIV surface, leading to membrane fusion and viral entry. CCR5 mRNA is expressed in lymphoid organs and monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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