Thermo Fisher Scientific HOXD11 Polyclonal Antibody
HOXD11 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. 인간, 마우스, 랫트 시료에 반응하며 Western blot에 적합. 고순도 친화 크로마토그래피 정제, 1 mg/mL 농도, -20°C 보관.
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HOXD11 (Accession P31277), corresponding to amino acid residues G206–K256 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853227 |
Product Specific Information
Antibody detects endogenous levels of total HOXD11.
Target Information
HOX11, also called homeobox11 or Tcl-3, is located at the 10q24 T-cell translocation breakpoint region. It encodes a homeobox-domain containing protein with a glycine and proline-rich amino terminus. HOX11 is required for spleen development and cell survival. The protein binds specific DNA sequences and localizes to the nucleus, acting as a positive transcription activator.
HOX11 gene is highly expressed in T-ALLs due to translocations such as t(7:10)(q35;q24) or t(10:14)(q24;q11), leading to deregulation and activation of tumor-associated target genes. These translocations are associated with T-cell leukemia and lymphoid neoplasias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-103895_HOXD11_P31277-1_Rabbit_PDP.jpeg)
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