Thermo Fisher Scientific Lactoferrin Monoclonal Antibody (1C6)

Applications

Western Blot (WB)

• Tested Dilution: Assay-dependent

ELISA

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

MA1-20059 detects lactoferrin in human samples.

Target Information

Lactoferrin (LF) is an iron-binding glycoprotein composed of a single polypeptide chain (~80 kDa) folded into two homologous lobes, each capable of reversibly binding one ferric ion (Fe³⁺). It is present in external fluids such as milk and mucosal secretions and in neutrophil secondary granules.
LF plays diverse roles including:

• Regulation of iron homeostasis
• Host defense against microbial infections
• Anti-inflammatory activity
• Regulation of cellular growth and differentiation
• Protection against cancer development and metastasis

Lactoferrin acts as a major first-line defense against microbial infections through Fe³⁺ sequestration and exhibits bactericidal and proteolytic activity. Three isoforms (α, β, γ) have been identified, and receptors for LTF are expressed in the gastrointestinal tract, macrophages, lymphocytes, neutrophils, platelets, and some bacteria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.