Thermo Fisher Scientific NEDD4 Polyclonal Antibody
인간 NEDD4 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체입니다. Western blot에 최적화되어 있으며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 PBS/50% 글리세롤 버퍼에 저장됩니다. 연구용 전용 제품입니다.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein of human NEDD4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.61 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein containing one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It participates in the degradation pathway of VEGFR-2/KDFR independently of its ubiquitin-ligase activity. NEDD4 acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, similar to Mdm2 and p53. It is involved in viral budding and regulates epithelial Na⁺ channels, contributing to arterial hypertension. NEDD4 localizes to the sarcolemmal region of muscle fibers, and increased expression is associated with muscle unloading and denervation, as well as decreased Notch1 expression. Thus, it functions as a downregulator of Notch-1 gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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