
Thermo Fisher Scientific NTHL1 Polyclonal Antibody
Thermo Fisher Scientific의 NTHL1 Polyclonal Antibody는 인간 및 생쥐에 반응하는 rabbit IgG 항체로, Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 50% glycerol buffer에 보관됩니다. 산화적 DNA 손상 복구 연구에 활용됩니다.
- 카탈로그번호
- TA890138
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 1:500–1:2,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein of human NTHL1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.28 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Oxygen radicals damage chromosomal DNA, leading to cell death and mutations. While much attention has focused on repairing 8-oxo-G lesions, many other DNA sites are damaged by free radicals. The human NTH1 repair protein acts on a wide range of these oxidatively damaged DNA sites. As a homologue of E. coli Endonuclease III, NTH is a DNA glycosylase with apurinic/apyrimidinic lyase activity. It exhibits broad substrate specificity, targeting various ring saturation and fragmentation products of pyrimidines. Research indicates that NTH plays a crucial role in removing oxidative base lesions in mitochondrial DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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