Thermo Fisher Scientific TRMT12 Monoclonal Antibody (OTI3C10)
TRMT12 단백질을 표적으로 하는 Mouse IgG2a 단클론 항체로 Western blot과 IHC(Paraffin)에 사용 가능. 인간 반응성, 액상 형태, 1 mg/mL 농도. 연구용으로만 사용되며, TRMT12 관련 단백질 발현 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3C10 |
| Immunogen | Full length human recombinant protein of TRMT12 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725579 |
Target Information
TYW2, also known as TRM12, is an enzyme involved in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine located adjacent to the anticodon of phenylalanine tRNA and stabilizes codon-anticodon interactions during ribosomal decoding.
TYW2 participates in a multistep enzymatic reaction that ensures correct translation through stabilization of codon-anticodon base-pairing.
TYW2 amplification was observed in 7 of 8 breast cancer cell lines, and qPCR analysis of 30 breast tumors showed overexpression (>2-fold) in 26 samples, suggesting a potential role in breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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