Thermo Fisher Scientific Haptoglobin (HP) Monoclonal Antibody (HP/3837)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Antibody is stable for 24 months.
• Positive Control: Human liver
• Cellular Localization: Secreted
• Selective granular cytoplasmic expression in liver with distinct positivity in plasma and extracellular matrix.

Specificity Comments

Haptoglobin (Hp) is a blood plasma protein that binds free hemoglobin released from erythrocytes, inhibiting its oxidative activity. This binding sequesters iron within hemoglobin, preventing iron-utilizing bacteria from benefiting from hemolysis. Haptoglobin concentrations may increase in response to inflammation. The Haptoglobin-Hemoglobin complex is removed by the reticulo-endothelial system.

Haptoglobin consists of two α and two β chains connected by disulfide bridges. In humans, two allelic forms exist: Hp1 and Hp2, with three phenotypes (Hp1-1, Hp2-1, Hp2-2) associated with various diseases such as diabetes, cardiovascular disease, Parkinson’s, and Crohn’s disease. Haptoglobin levels are useful in diagnosing hemolytic anemia. It is expressed in hepatocytes and tissues such as skin, lung, and kidney.

Target Information

Haptoglobin is an α2-globulin plasma protein synthesized in the liver. It functions as an acute phase protein and scavenger of hemoglobin from hemolyzed red cells. The monomer consists of two α and two β chains; α chains may be hp1Fa, hp1Sa, or hp2a types, while the β chain is constant. Three major phenotypes (Hp1-1, Hp2-1, Hp2-2) are recognized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.