Thermo Fisher Scientific CD38 Monoclonal Antibody (90), APC, eBioscience

Applications and Tested Dilution

• Application: Flow Cytometry (Flow)
• Tested Dilution: 0.06 µg/test
• Publications: View 25 publications

Product Specifications

Additional Formats Available

• Unconjugated
• Alexa Fluor 700
• APC-eFluor 780
• Biotin
• Brilliant UV 395
• Brilliant Violet 480
• Brilliant Violet 605
• eFluor 450
• FITC
• Functional Grade
• PE
• PE-Cyanine5
• PE-Cyanine7
• PE-eFluor 610
• PerCP-eFluor 710
• Request custom conjugation

Product Specific Information

The 90 monoclonal antibody reacts with the mouse CD38 molecule (~42 kDa type II transmembrane protein). CD38 is expressed at increasing levels during B-cell differentiation and down-regulated on germinal center B cells and mature plasma cells. It is also expressed on subsets of thymocytes, mature T cells, and NK cells.

Crosslinking of CD38 on mature B cells induces proliferation, enhanced by IL-4 and LPS. CD38 acts as a counter-receptor for CD31 and functions as an ectoenzyme with cyclase and hydrolase activity, playing a role in lymphocyte activation and differentiation.

• Applications Reported: Flow cytometric analysis
• Applications Tested: Flow cytometric analysis of mouse splenocytes
  • Recommended ≤ 0.06 µg/test
  • Test volume: 100 µL
  • Cell range: 10⁵–10⁸ cells/test
  • Optimize antibody titration for best performance
• Excitation: 633–647 nm
• Emission: 660 nm
• Laser: Red Laser
• Filtration: 0.2 µm post-manufacturing filtered

Target Information

CD38 (NAD⁺ glycohydrolase) is a type II transmembrane glycoprotein involved in activation, proliferation, and differentiation of lymphocytes, and in apoptosis of myeloid and lymphoid progenitor cells. It functions as a multi-catalytic ectoenzyme (ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, NAD⁺ glycohydrolase) and as a receptor.

Antibodies to CD38 are useful for:

• Subtyping lymphomas and leukemias
• Detecting plasma cells (e.g., myelomas)
• Identifying activated B and T cells

CD38 participates in cell adhesion, signal transduction, and calcium signaling. It is highly expressed in pancreas, liver, kidney, malignant lymphoma, and neuroblastoma. Dysregulation is associated with chronic lymphocytic leukemia and Richter’s Syndrome.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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