Thermo Fisher Scientific TNFSF8 Monoclonal Antibody (4E4)
TNFSF8 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot 및 ELISA에 사용 가능. 인간 시료에 반응하며, PBS buffer에 보관. CD30/CD153 연구 및 림프종 관련 면역학 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4E4 |
| Immunogen | TNFSF8 (AAH93630.1, 63 a.a. ~234 a.a) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
QRTDSIPNSP DNVPLKGGNC SEDLLCILKR APFKKSWAYL QVAKHLNKTK LSWNKDGILH GVRYQDGNLV IQFPGLYFII CQLQFLVQCP NNSVDLKLEL LINKHIKKQA LVTVCESGMQ TKHVYQNLSQ FLLDYLQVNT TISVNVDTFQ YIDTSTFPLE NVLSIFLYSN SD
Target Information
The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death.
CD30 plays a critical role in the pathophysiology of Hodgkin’s disease and other CD30+ lymphomas. It acts as a costimulatory molecule in thymic negative selection.
CD30 is expressed on Hodgkin’s and Reed-Sternberg cells, some non-Hodgkin’s lymphomas (including Burkitt’s), virus-infected T and B cells, and activated normal T and B cells.
In T cells, CD30 expression is found on subsets producing Th2-type cytokines and on CD4+/CD8+ thymocytes coexpressing CD45RO and IL4 receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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