Thermo Fisher Scientific PSMD1 Polyclonal Antibody
Thermo Fisher Scientific의 PSMD1 Polyclonal Antibody는 Western blot, IHC, IP 등에 사용 가능한 Rabbit IgG 항체입니다. 인간 PSMD1 단백질의 903–953번 잔기 영역을 면역원으로 하며, 비결합형 액상 형태로 제공됩니다. 4°C 보관, 습빙 상태로 배송됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 903 and 953 of Human Proteasome (Prosome, Macropain) 26S Subunit, non-ATPase, 1 (PSMD1, UniProt ID: Q99460-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Rat, Chicken, and Orangutan
Target Information
Proteolytic degradation is essential for maintaining appropriate levels of short-lived and regulatory proteins involved in cellular metabolism, stress response, antigen presentation, receptor modulation, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway degrades most cytosolic and nuclear proteins in eukaryotic cells, while others are processed via the vacuolar pathway involving endosomes, lysosomes, and the endoplasmic reticulum.
The 26S proteasome is an ATP-dependent, multisubunit (~31) complex with an approximate molecular weight of 2.5 MDa. It consists of a 20S proteolytic core capped by 19S regulatory subunits that recognize ubiquitinated proteins and facilitate their unfolding and translocation.
Defects in this pathway are associated with genetic diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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