Thermo Fisher Scientific ALDH3A2 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Keep as a concentrated solution.
• Predicted reactivity: Mouse (88%), Rat (89%), Bovine (86%).
• Positive Control: HeLa, HeLa membrane.
• Centrifuge briefly prior to opening the vial.

Target Information

Aldh3A2 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. These enzymes are involved in detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation.
Aldh3A2 catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Mutations in the Aldh3A2 gene cause Sjogren-Larrson syndrome, an inherited neurocutaneous disorder characterized by ichthyosis, mental retardation, and spastic diplegia. The pathogenesis is thought to result from abnormal lipid accumulation in skin and brain membranes, aldehyde Schiff base adduct formation, or defective eicosanoid metabolism.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.