Thermo Fisher Scientific Prion protein PrP Polyclonal Antibody
Prion protein(PrP)에 특이적인 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에 반응합니다. IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능하며 Protein A로 정제된 고순도 항체입니다. 연구용으로만 사용되며 CJD 등 프리온 관련 연구에 적합합니다.
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Applications 및 권장 희석 배율
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Major prion protein (amino acids 51–150) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein that associates with lipid raft components and functions as a signaling molecule.
PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells, and in the distribution of junction-associated proteins in human enterocytes.
Conversion of the normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of prion neurodegenerative disorders, such as Creutzfeld-Jakob disease (CJD).
Whereas PrPc is rich in alpha-helices, the PrPSc form has higher beta-sheet content and is resistant to proteinase K.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: BS-4728R_PrP_P04156-1_Rabbit.svg, BS-4728R_PrP_P04156-1_Rabbit_PDP.jpeg)
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