Thermo Fisher Scientific IL-17A Polyclonal Antibody
IL-17A에 특이적인 Rabbit Polyclonal Antibody로 인간 및 마우스 시료에 반응합니다. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 염증 반응 연구 및 사이토카인 신호 분석에 활용 가능합니다.
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Thermo Fisher Scientific IL-17A Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.125–0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Anti-IL-17 antibody was raised against a peptide corresponding to 16 amino acids near the center of mature human IL-17. The immunogen is located within amino acids 50–100 of IL-17. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2890392 |
Product Specific Information
Positive controls that may be used include: A20 Cell Slide
Target Information
Interleukin-17A (IL-17A, CTLA-8) is a CD4⁺ T cell-derived cytokine that promotes inflammatory responses in various cell lines. It is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection.
IL-17A is a 32 kDa disulfide-linked homodimer consisting of 136 amino acids and belongs to a six-member family (IL-17A–F). It signals through the IL-17 receptor (IL-17R/CDw217).
Activated peripheral blood CD4⁺ T-cells produce high levels of IL-17A, which enhances ICAM-1 expression in human fibroblasts and stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2.
In the presence of IL-17A, fibroblasts can sustain proliferation of CD34⁺ hematopoietic progenitors and induce neutrophil maturation. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating cross-species receptor recognition.
IL-17A regulates NF-κB and MAPK activities, stimulates IL-6 and COX-2 expression, and enhances nitric oxide (NO) production.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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