Thermo Fisher Scientific SCO2 Polyclonal Antibody
SCO2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC(P), ELISA에 적합합니다. Human, Mouse, Rat 시료에 반응하며, Affinity chromatography로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
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- PA5117084
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 100–266 of human SCO2 (NP_005129.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.51 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901714 |
Product Specific Information
Positive Samples: 293T, HL-60, SKOV3, Mouse spleen, Mouse brain, Rat spleen
Immunogen Sequence:
GQGDFHLLDH RGRARCKADF RGQWVLMYFG FTHCPDICPD ELEKLVQVVR QLEAEPGLPP VQPVFITVDP ERDDVEAMAR YVQDFHPRLL GLTGSTKQVA QASHSYRVYY NAGPKDEDQD YIVDHSIAIY LLNPDGLFTD YYGRSRSAEQ ISDSVRRHMA AFRSVLS
Target Information
Synthesis of cytochrome c oxidase 2 (SCO2) was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane.
Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding.
Recent studies suggest that SCO2 expression is regulated by p53, and a decrease in p53 expression—such as in numerous tumors and cell lines—leads to reduced SCO2 expression, shifting metabolism from normal aerobic respiration toward glycolytic ATP production.
Defects in the SCO2 protein are associated with fatal infantile cardioencephalomyopathy and COX deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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