Thermo Fisher Scientific SMC1 Polyclonal Antibody
Thermo Fisher Scientific의 SMC1 Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하는 Rabbit IgG 항체입니다. Western blot 및 ELISA에 적합하며, SMC1 단백질 연구에 활용됩니다. 고순도 Affinity chromatography 정제 제품으로 안정적인 PBS/glycerol buffer에 보관됩니다.
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Applications
Western Blot (WB)
ELISA (ELISA)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–130 of human SMC1 (NP_0062972) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.31 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2901712 |
Product Specific Information
Positive Samples:
22Rv1, NCI-H460, HeLa, 293T, SKOV3, Mouse liver, Mouse spleen, Mouse pancreas, Rat liver
Immunogen sequence:
MGFLKLIEIE NFKSYKGRQI IGPFQRFTAI IGPNGSGKSN LMDAISFVLG EKTSNLRVKT LRDLIHGAPV GKPAANRAFV SMVYSEEGAE DRTFARVIVG GSSEYKINNK VVQLHEYSEE LEKLGILIKA
Target Information
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair, and global transcriptional repression.
These chromosomal proteins are conserved in eukaryotes and defects can cause mitotic chromosome segregation errors, suggesting a critical role in chromosome dynamics.
SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells, specifically responsible for sister chromatid cohesion. Mutations in the SMC1 gene can lead to Cornelia de Lange syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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