Thermo Fisher Scientific MTHFD1 Polyclonal Antibody
Human, Mouse, Rat에 반응하는 Rabbit Polyclonal 항체로, Western Blot 및 IHC(P) 분석에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 버퍼에 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MTHFD1. Recombinant protein control fragment (Product # RP-88919). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2789050 |
Product Specific Information
Immunogen sequence:
LNGKEISAQI RARLKNQVTQ LKEQVPGFTP RLAILQVGNR DDSNLYINVK LKAAEEIGIK ATHIKLPRTT TESEVMKYIT SLNEDSTVHG FLVQLPLDSE NSINTEEVIN AIAPEKDVDG LTSINAGRLA RGDLNDCFIP CT
Target Information
This gene encodes a protein that possesses three distinct enzymatic activities:
- 5,10-methylenetetrahydrofolate dehydrogenase
- 5,10-methenyltetrahydrofolate cyclohydrolase
- 10-formyltetrahydrofolate synthetase
Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses.
The trifunctional enzymatic activities are conferred by two major domains:
- An aminoterminal portion containing the dehydrogenase and cyclohydrolase activities
- A larger synthetase domain
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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