Thermo Fisher Scientific ATG13 Polyclonal Antibody
ATG13 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC, ELISA 등 다양한 응용 가능. 인간, 생쥐, 랫트 반응성. KLH 결합 합성 펩타이드(aa 51–150)로 면역화. 단백질 A 정제, 1 mg/mL 농도, -20°C 보관.
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Thermo Fisher Scientific ATG13 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human ATG13 (amino acids 51–150) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Autophagy is a process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway, essential for normal growth control and nutrient preservation under starvation. It is negatively regulated by TOR (Target of Rapamycin) via phosphorylation of autophagy protein ATG1.
ATG13 forms a complex with ULK1, ULK2, and FIP200, which is a target of TOR phosphorylation. Inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1, and ULK2, initiating autophagy. Knockdown of ATG13 inhibits autophagosome formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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