Thermo Fisher Scientific ASGR1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.25 µg/mL

Neutralization (Neu)

• Tested Dilution: Assay-Dependent

Product Specifications

Product Specific Information

• Reconstitute at 0.2 mg/mL in sterile PBS.
• Endotoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

Target Information

The asialoglycoprotein receptor (ASGPR) is a 42 kDa transmembrane glycoprotein that mediates binding, internalization, and degradation of extracellular glycoproteins with exposed terminal galactose residues.
It is expressed on hepatocyte surfaces in a polar manner—present on sinusoidal and lateral plasma membranes but absent on bile canalicular membranes.
Mammalian hepatic ASGPR mediates endocytosis and degradation of serum proteins lacking terminal sialic residues.
The rat ASGPR consists of three subunits: RHL-1, RHL-2, and RHL-3.
Monoclonal antibody 8D7 recognizes a subunit-specific epitope of RHL-1 in rat ASGPR and shows cross-reactivity with human ASGPR.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.