Thermo Fisher Scientific ASCL1 Polyclonal Antibody
ASCL1 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, 인간 시료에 반응합니다. Western blot에 적합하며, 고순도 Protein A 및 항원 친화 크로마토그래피로 정제되었습니다. 신경계 발달 및 신경내분비 종양 연구에 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 63–90 amino acids from the N-terminal region of human ASCL1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.36 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2552540 |
Target Information
ASCL1 (also known as ASH1) is a basic helix-loop-helix transcription factor required for early development of the nervous system. It is expressed in the fetal brain and essential for the proper development and survival of subsets of autonomic neurons. ASCL1 interacts with MEF-2A to regulate gene expression critical for neuronal circuit formation in the central nervous system. High ASCL1 expression in neuroendocrine tumors such as medullary thyroid cancer and small cell lung cancer makes it a useful marker for cancers with neuroendocrine features. The ASCL1 gene maps to human chromosome 12 and contains a trinucleotide repeat region, suggesting a potential role in inherited disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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